How to Modafinil Use in Mild Cognitive Impairment

Modafinil is an approved wake-promoting agent used to treat sleepiness due to narcolepsy or obstructive sleep apnea. It also improves global mental status, hippocampal neurogenesis, and attention. Modafinil improves cognitive function in healthy adults and patients with ADHD. This includes improving spatial planning, visual pattern recognition memory, digit span, and response inhibition.

How to take it

Narcolepsy and other sleep disorders are the main conditions Modvigil 200 Buy Online is used to treat, although it can also improve cognitive abilities including alertness and attention. This is known as “off-label” use and has led to an increased interest in modafinil’s effect on cognition, according to Psychiatric News.

For example, a study of cancer patients with chemotherapy-induced cognitive impairment found that modafinil was a good choice of medication to improve their memory. The smart pill was found to increase their score on a memory test called the Montreal Cognitive Assessment.

Another study found that modafinil was effective in treating fatigue in people with HIV/AIDS. A double-blind trial compared modafinil with a placebo and found that it significantly improved fatigue scores.

Researchers are now looking at whether the same effect can be achieved in people who have relapsed from depression. They’re also testing whether a morning dose of modafinil can enhance cognition in healthy individuals and improve their circadian rhythm. In addition, researchers are trying to find out if modafinil can mitigate cognitive deficits in Alzheimer’s disease and bipolar depression.

Major functional consequences of schizophrenia’s cognitive impairments. The cognitive enhancer modafinil has been shown to improve cognition in healthy volunteers, although its effects on schizophrenia-related cognitive deficiencies are unclear. The sensitivity of cognitive test batteries varies, or the stage of sickness may be significant, with individuals responding better towards the beginning of their illness, as two potential explanations.

Depression does characterize by cognitive impairment, which frequently lasts even after mood symptoms subside and has a negative impact on clinical and functional results. The majority of already accessible medicines, however, have not frequently address cognition.

As modafinil has been demonstrate to have positive effects on cognitive function, it may be able to enhance cognition in depressive patients. This double-blind, placebo-controlled study’s goal was to find out how modafinil affected patients with remitted depression’s cognitive abilities.


Modafinil does use to treat narcolepsy (a sleep disorder) and obstructive sleep apnea (a breathing disorder that makes it hard to fall asleep). It comes in tablets, capsules, or liquid. It does take by mouth with or without food as direct by your doctor, usually once a day in the morning.

In addition to narcolepsy, modafinil has been studied for other conditions that cause fatigue such as multiple sclerosis, treatment-resistant depression, and ADHD. A few studies have found that it can improve performance on some cognitive tests in these patients, compared with a placebo (Table 3).

In addition to its stimulant effects, modafinil does also believes to stimulate the synthesis of GABA and glutamate by brain cells in the hypothalamus and central nervous system. It also interacts with the dopamine D1 receptor, a dopamine transporter that does locate in the prefrontal cortex. The D1 receptor does involve in cognitive functions such as working memory and decision-making.

Side effects

Originally develop as a wake-promoting medicine for people with sleep disorders. Modafinil does now also use off-label to improve cognitive function in healthy individuals. The drug does think to promote alertness and concentration, helping people with exam preparation, for example.

This medication is not safe for pregnant women or for anyone who is trying to become pregnant. It can cause serious skin rashes, including Stevens-Johnson Syndrome (SJS).

If you are pregnant or planning to become pregnant, discuss with your doctor the benefits and risks of using modafinil. Use another form of birth control during treatment. And for at least a month after your last dose of this medicine.

The study is a randomized, double-blind, placebo-controlled trial in elderly male and female subjects with mild cognitive impairment (SCD). Participants do randomize to receive either modafinil 200mg QD or placebo qd for 7 weeks. They will complete questionnaires and neurocognitive tests during the study.


Modafinil is a controlled substance (Schedule IV). This means it has an accept medical use but may also cause physical or psychological dependence and may be abuse.

Physicians should follow patients closely for signs of misuse or abuse. The medicine should be keep away from children.

In rare cases, serious allergic reactions may occur (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms [DRESS]). Discontinue the medicine at the first sign of a serious rash, unless the rash is clearly not drug related.

A morning dose can be helpful for people with an imbalance in their circadian rhythm. And who have difficulty waking up at the same time every day. However, it’s important to take the dose as directed and to store the medicine in a safe place. If you’re having trouble remembering to take the medication, talk to your doctor.

As modafinil has been demonstrat to have positive effects on cognitive function. It may be able to enhance cognition in depressive patients. This double-blind, placebo-controlled study’s goal was to find out how modafinil affected patients with remitted depression’s cognitive abilities.

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